ABSTRACT
Neurodegenerative disorders (NDD) are chronic neurological diseases characterized by loss and/or damage to neurons along with the myelin sheath, and patients are at higher risk of severe infection with the SARSCoV2. A comprehensive literature search was performed using relevant terms and inclusionexclusion criteria. Recent articles, subjects older than 50 years, and articles written in the English language were included, whereas letters to the editor and articles related to pregnant women were excluded from the review study. COVID19 appears to damage angiotensinII receptors which cause natural killer cells to lose the ability to clear virusinfected cells, owing to worse outcomes in patients with NDD. COVID19 can worsen the symptoms of Alzheimer's disease. In addition, COVID19 worsens drugresponsive motor symptoms in Parkinson's disease (PD) and other symptoms like fatigue and urinary complaints. Vitamin D is essential in decreasing proinflammatory and increasing antiinflammatory cytokines in ongoing COVID19 infections and reducing angiotensin receptors and, hence, decreasing COVID19 infection severity. Telemedicine shows promise for patients with NDD but is yet to overcome legal issues and personal barriers. COVID19 has a significant effect on neurodegenerative conditions, which appears partly to the nature of the NDD and the neuroinvasive capabilities of the SARSCoV2. The protective role of vitamin D in patients with NDD further supports this hypothesis. Modifications in current health care, like the telemedicine platform, are required to address the increased risk of serious infection in this population. Further studies will be required to clarify conflicting reports in many fields.